Dr. Tangudu's paper on ATR-mediated cholesterol synthesis and mTORC1 activation accepted and online at EMBO Reports!

Congratulations to Dr. Tangudu on this very interesting finding linking the DNA damage response protein ATR to mTORC1 activation through a non-canonical role in cholesterol metabolism. You can read the paper here: https://www.embopress.org/doi/full/10.1038/s44319-025-00451-3

This was a close collaboration with Dr. Alex Valvezan’s lab at Rutgers. His lab had also independently discovered a connection between ATR and mTORC1, and we joined efforts to publish this work.