New preprint on alpha-ketoglutarate and histone acetylation- congrats Dr. Apoorva Uboveja and co-authors

We are excited to share our newest preprint from 1st author Dr. Apoorva Uboveja. In this project, she found something totally unexpected- aKG affects histone acetylation through carnitine synthesis. This axis promoted DNA repair by homologous recombination. These data provide new evidence for a metabolically-sensitive epigenetic axis that could be targeted for cancer therapy. They also show that methylation is not the only epigenetic change that is affected by aKG. https://www.biorxiv.org/content/10.1101/2024.02.06.578742v1