Congrats to Kelly for getting her first author paper out the door! She found that H3K79me2/3 and the H3K79 histone methyltransferase DOT1L are increased in oncogene-induced senescent cells to promote increased transcription of the upstream SASP regulator IL1A. You can read the preprint here: doi.org/10.1101/2020.08.21.258020
Congrats to Raquel for getting this small paper out the door during these hard times. She found that p16 loss decreases IL6 and IL8 (two of the main effectors of the SASP), which is uncoupled from its role in the cell cycle. These studies have potential implications for understanding the tumor microenvironment of p16-low tumors, and we are planning to do more studies in the area with our new immunology colleagues at Pitt. Read the preprint here: https://www.biorxiv.org/content/10.1101/2020.08.19.257717v1
We have big news to share- starting Sept 1, the Aird lab will be a part of the Hillman Cancer Center at the University of Pittsburgh! We are so excited for this next chapter!
We are hiring at multiple levels- postdocs and technicians/lab managers. Email us to learn more!
Congrats to Daniel for his 2nd preprint of the year! He found that ATM inhibition synergizes with the FDA-approved drug fenofibrate in ovarian cancer cell lines. You can read more: https://www.biorxiv.org/content/10.1101/2020.05.29.123919v1
Hats off to Daniel, who submitted his first paper from the lab today. He found that inhibition of ATM induces nutrient uptake via macropinocytosis- a non-specific endocytic process. This discovery adds to growing evidence that ATM has tumor suppressive roles outside of the canonical DNA damage response pathway. You can read the preprint here.
The lab’s first R01 was awarded and converted to an R37 MERIT Award (7 years of funding)! These studies will follow up and expand upon Dr. Raquel Buj’s work on how p16 loss affects nucleotide metabolism.
Both Erika and Kelly received oral presentations for Penn State’s Annual Graduate Student Research Forum! They did an outstanding job!
Congratulation to grad student Kelly Leon for receiving her NCI F31 Notice of Award today! She wrote a beautiful proposal and got an amazing score- so much hard work paid off! She will study how the epigenome affects the senescence-associated secretory phenotype in cancer.
Happy New Year! With recent grant success, we have funds for another postdoctoral scholar to join the lab. We have a number of projects related to cellular metabolism in both cancer and senescence. See our ad below for more details and do not hesitate to reach out!
The lab recently participated in the Sandy Sprint to raise funds for ovarian cancer research for the Sandy Rollman Ovarian Cancer Foundation. Penn State College of Medicine wrote an article about the event and our work. Read the article here
Kelly, Erika, Raquel, and Katherine attended the 2nd Annual Midwest Metabolism Meeting hosted by Rusty Jones at the Van Andel Institute in Grand Rapids. It was an excellent meeting, and everyone had the opportunity to present their work. See the schedule here: https://vari.vai.org/event/midwest-metabolism-meeting-2019/
Congratulations to graduate student Kelly Leon who received a truly outstanding score on her NCI F31. We are so proud of this huge accomplishment! This grant will fund her work on the epigenetic changes that lead to chemoresistance in ovarian cancer.
The Lyssiotis lab (U of Michigan) wrote a Highlight of our Cell Reports paper in Trends in Biochemical Sciences! Read the highlight here
Katherine’s American Cancer Society Research Scholar Grant was recently funded! The grant will help us better understand metabolic dysregulation early in ovarian tumorigenesis and determine whether metabolic inhibitors can be used in combination with PARP inhibitors to improve ovarian cancer therapy.
The International Cellular Senescence Association meeting is underway in Athens. Raquel was chosen for a short talk, and both Kelly and Erika presented posters of their work.
Raquel giving a talk on her recently published work on how p16 loss increases nucleotide metabolism to bypass senescence.
Kelly presenting her work on how the methyltransferase DOT1L is critical for the SASP
Erika presenting her work on senescence in the omentum and how that potentially relates to ovarian cancer dissemination
Erika Dahl, 4th year graduate student, received the Patrick G. Quinn award for outstanding post-candidacy doctoral student in C&M Physiology department on Friday at the Antique Auto Museum. Congrats Erika!
Congratulations to Raquel and the lab for publishing this exciting story! She found that loss of p16 increases nucleotide metabolism via mTORC1-mediated translation of the pentose phosphate pathway enzyme RPIA. Excitingly, inhibition of this pathway may be a new therapeutic strategy for the ~50% of cancer patients with low p16 expression.
You can read the paper here.
Raquel’s paper describing a new, cell cycle-independent role for p16 loss in promoting pro-tumorigenic nucleotide metabolism has been accepted by Cell Reports. You can read the preprint on bioRxiv here.
Congratulations to Raquel!
Our publication on IDH1 was recently featured in a press release from Penn State. See the article here.
Graduate student Kelly Leon presented her work on the epigenetic control of the senscence-associated secretory phenotype. It was a great day of clinical and basic science! Postdoc Daniel Chen presented his work on glucose regulation in ATM inhibitor-treated cells. It was a great day of clinical and basic science!
